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World J Exp Med. May 20, 2014; 4(2): 16-26
Published online May 20, 2014. doi: 10.5493/wjem.v4.i2.16
Published online May 20, 2014. doi: 10.5493/wjem.v4.i2.16
Wound healing reaction: A switch from gestation to senescence
Maria-Angeles Aller, Jaime Arias, Surgery Department, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
Jose-Ignacio Arias, General Surgery Unit, Monte Naranco Hospital, Monte Naranco Hospital, Oviedo, Asturias, 33012 Oviedo, Spain
Luis-Alfonso Arraez-Aybar, Department of Human Anatomy and Embryology II, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
Carlos Gilsanz, General Surgery Unit, Sureste Hospital, Arganda del Rey, 28040 Madrid, Spain
Author contributions: Arias JI and Gilsanz C revised the bibliography about wound healing; Arraez-Aybar LA revised the mechanisms involved in embryonic development; Aller MA and Arias JI integrated all the revised knowledge and wrote the final version of the manuscript.
Correspondence to: Jaime Arias, MD, PhD, Surgery Department, School of Medicine, Complutense University of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. jariasp@med.ucm.es
Telephone: +34-91-3941388 Fax: +34-91-3947115
Received: June 5, 2013
Revised: February 28, 2014
Accepted: March 13, 2014
Published online: May 20, 2014
Revised: February 28, 2014
Accepted: March 13, 2014
Published online: May 20, 2014
Core Tip
Core tip: In this review, we propose an integrative molecular point of view about wound healing. Wound healing could be associated with the upregulation of functions characteristic of embryonic development. The repair of adult tissues using upregulated embryonic mechanisms could explain the ubiquity of the inflammatory response against injury, regardless of its etiology.