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World J Exp Med. Nov 20, 2013; 3(4): 74-86
Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.74
Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.74
Mechanotransduction in bone: Intervening in health and disease
Anastasia Spyropoulou, Efthimia K Basdra, Department of Biological Chemistry, Cellular and Molecular Biomechanics Unit, University of Athens Medical School, GR-11527 Athens, Greece
Author contributions: Spyropoulou A and Basdra EK contributed to this paper equally.
Correspondence to: Efthimia K Basdra, PhD, Associate Professor, Department of Biological Chemistry, Cellular and Molecular Biomechanics Unit, University of Athens Medical School, 75, M. Asias Street, GR-11527 Athens, Greece. tegk.84@gmail.com
Telephone: +30-210-7462547 Fax:+30-210-7791207
Received: June 28, 2013
Revised: September 27, 2013
Accepted: November 1, 2013
Published online: November 20, 2013
Revised: September 27, 2013
Accepted: November 1, 2013
Published online: November 20, 2013
Core Tip
Core tip: Mechanotransduction has been shown to be of major significance in modulating bone remodeling under physiological and pathological conditions. Therefore the study of the underlying mechanisms is of major importance and necessary step towards the better understanding of bone biology as well as the development of therapeutic strategies against conditions characterised by deregulated mechanotransduction. This review will consider the molecular mechanisms behind mechanotransduction as well as the scientific models currently used for its better understanding. It will also focus on mechanostimulatory techniques that could be used against a variety of deregulated mechanotransduction-related diseases.