Published online Aug 20, 2013. doi: 10.5493/wjem.v3.i3.34
Revised: July 8, 2013
Accepted: August 16, 2013
Published online: August 20, 2013
Core tip: Recent evidence has shown that the constellation of obesity, insulin resistance and adipokines is associated with the risk and prognosis of postmenopausal breast cancer (BC). Direct evidence is growing rapidly supporting the stimulating and/or inhibiting role of adipokines in the process of development and progression of BC. Recent studies support a role of adipokines as novel risk factors and potential diagnostic and prognostic biomarkers in BC. This editorial aims at providing important insight into the potential pathophysiological mechanisms linking adipokines to the etiopathogenesis of BC in the context of a dysfunctional adipose tissue and insulin resistance in obesity. Understanding of these mechanisms may be important for the development of attractive preventive and therapeutic strategies against obesity-related breast malignancy.