Clinical Trials Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Mar 20, 2024; 14(1): 88541
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.88541
Impact of primary percutaneous coronary intervention on ST-segment elevation myocardial infarction patients: A comprehensive analysis
Eza Nawzad Saeed, Abdulsatar Kamil Faeq
Eza Nawzad Saeed, Abdulsatar Kamil Faeq, Department of Medicine, Hawler Medical University, Erbil 44001, Kurdistan, Iraq
Author contributions: Faeq AK provided supervision for the project; Saeed EN was responsible for data collection and curation, reviewing and draft preparation.
Institutional review board statement: The study protocol received approval from the Institutional Review Board (IRB) at Hawler Medical University. All research procedures and data collection methodologies were conducted according to the principles of the Declaration of Helsinki and other relevant national and institutional ethical guidelines.
Clinical trial registration statement: This study is registered at college of medicine -Hawler medical university. The registration is required for complete M.Sc.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper. All authors have contributed significantly to the research and preparation of the manuscript and have approved the final version for submission. No external funding was received for this research.
Data sharing statement: Original contributions reflected in this work can be obtained from the article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eza Nawzad Saeed, MBChB, Researcher, Department of Medicine, Hawler Medical University, Erbil - IRAQ 44001, Erbil 44001, Kurdistan, Iraq. demolali542@gmail.com
Received: September 27, 2023
Peer-review started: September 27, 2023
First decision: January 2, 2024
Revised: January 8, 2024
Accepted: February 2, 2024
Article in press: February 2, 2024
Published online: March 20, 2024
ARTICLE HIGHLIGHTS
Research background

The Erbil Cardiac Center studied 96 patients with ST-segment elevation myocardial infarction (STEMI), treated by primary percutaneous coronary intervention (PPCI). Key factors influencing survival rates included clinical features, procedure details, and the time from symptom onset to hospital arrival. Prompt intervention significantly improved outcomes. Understanding these factors can enable better treatment strategies and public awareness campaigns, ultimately reducing mortality.

Research motivation

This study focuses on STEMI treatment, PPCI efficacy, and identifying mortality predictors. Key problems include identifying mortality predictors and determining onset-to-arrival time's role. Resolving these issues could enhance STEMI treatment, reduce time-to-treatment, and guide future STEMI and PPCI research endeavors, thereby improving patient outcomes and advancing cardiology and emergency medicine fields.

Research objectives

This STEMI study aspired to examine patient mortality rates, identify mortality predictors, and assess onset-to-door time impact. It successfully revealed specific mortality rates and predictors, and it confirmed the importance of prompt intervention. These findings provide a benchmark for treatment strategies, underscore the value of personalizing care, and inspire research on reducing delays and further exploring mortality predictors.

Research methods

The study aimed to assess STEMI patient mortality rates, identify in-hospital mortality predictors, and uncover the impact of onset-to-hospital time using data analysis methods for a detailed evaluation. These objectives' fulfilment generates mortality benchmarks, guides new treatments, informs public health policies, and catalyzes future research, thereby contributing novel insights into STEMI patient care.

Research results

This study assessed STEMI patients, identifying mortality rates, mortality predictors, and onset-to-door time's significance on prognosis. The findings highlight early intervention importance, clarify mortality predictors, and stimulate personalized treatment plans to enhance PPCI effectiveness. Yet, underlying causes for hospital arrival delays, underlying processes of mortality predictors, and their generality across demographics need additional research.

Research conclusions

The study confirms the “time is muscle” theory, emphasizing swift intervention in STEMI cases, and broadens knowledge by identifying multiple mortality predictors. Though it proposes no new theories, methods, or phenomena, its insights improve our understanding of STEMI management. These findings don't imply confirmed hypotheses but provide a basis for future treatments and hypotheses in clinical practice.

Research perspectives

Future research should focus on reducing onset-to-door time by understanding delay causes, further exploring identified mortality predictors, verifying the study's findings in larger, diverse populations, and assessing novel STEMI treatments. Investigations may employ methods such as comprehensive data analysis, clinical trials, and patient education programs for these research directions.