Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome
Alpha A Fowler III, Rajiv Malhotra, Orlando Debesa, Ramesh Natarajan, Bernard J Fisher, Aamer Syed, Christine DeWilde, Anna Priday, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States
Christin Kim, Department of Anesthesia Critical Care, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States
Lawrence Lepler, Division of Critical Care Medicine, INOVA Fair Oaks Hospital, INOVA Health Care System, Fairfax, VA 22042, United States
Vigneshwar Kasirajan, Division of Cardiothoracic Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States
Author contributions: Fowler III AA is principal investigator, corresponding author, and contributed to study concept, basic and translational research; Kim C and Lepler L contributed to patient’s clinical care, patient follow-up and manuscript review; Malhotra R contributed to patient’s clinical care; Debesa O contributed to patient’s clinical care and manuscript review; Natarajan R and Fisher BJ contributed to manuscript creation, basic research leading to clinical use; Syed A and Kasirajan V contributed to clinical care and manuscript creation; DeWilde C contributed to clinical care and laboratory coordination; Priday A contributed to FDA regulatory coordinator for IND used for study.
Institutional review board statement: The use of intravenous vitamin C in humans has been approved by the Virginia Commonwealth University Institutional Review Board (HM20000917).
Informed consent statement: Permission for the patient to receive intravenous vitamin C as described in this case report was granted by the patient’s legal next of kin. All patient health information was de-identified and held in strictest confidentiality.
Conflict-of-interest statement: All authors have no conflicts of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alpha A Fowler III, MD, William Taliaferro Thompson Professor of Medicine, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University School of Medicine, 1200 East Broad Street, PO Box 980050, Richmond, VA 23298, United States. email@example.com
Telephone: +1-804-8289071 Fax: +1-804-8282578
Received: July 12, 2016
Peer-review started: July 13, 2016
First decision: September 2, 2016
Revised: October 26, 2016
Accepted: November 16, 2016
Article in press: November 17, 2016
Published online: February 4, 2017