Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Dec 18, 2020; 9(5): 88-98
Published online Dec 18, 2020. doi: 10.5492/wjccm.v9.i5.88
Vasopressin in vasoplegic shock: A systematic review
Andrew J Webb, Mohamed O Seisa, Tarek Nayfeh, Patrick M Wieruszewski, Scott D Nei, Nathan J Smischney
Andrew J Webb, Department of Pharmacy, Oregon Health and Science University, Portland, OR 97239, United States
Mohamed O Seisa, Tarek Nayfeh, Robert D and Patricia E Kern Center For The Science of Health Care Delivery, Mayo Clinic, Rochester, MN 55905, United States
Patrick M Wieruszewski, Scott D Nei, Department of Pharmacy, Mayo Clinic, Rochester, MN 55905, United States
Nathan J Smischney, Department of Anesthesia, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: All authors equally contributed to data collection, interpretation, and manuscript writing.
Conflict-of-interest statement: The authors have nothing to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Nathan J Smischney, MD, MSc, Assistant Professor, Department of Anesthesia, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States.
Received: August 1, 2020
Peer-review started: August 1, 2020
First decision: September 17, 2020
Revised: October 10, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: December 18, 2020
Core Tip

Core Tip: In this systematic review of vasopressin vs alternative vasoactive agents for the treatment of vasoplegic shock, vasopressin was not found to be superior to alternative pressor therapy for any of the included outcomes. However, results are limited by mixed methodologies, small overall sample size, and heterogenous populations.