Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Feb 4, 2018; 7(1): 1-8
Published online Feb 4, 2018. doi: 10.5492/wjccm.v7.i1.1
Effects of mineralocorticoid receptor antagonists on responses to hemorrhagic shock in rats
Kanako Yamamoto, Takashi Yamamoto, Masayuki Takamura, Soichiro Usui, Hisayoshi Murai, Shuichi Kaneko, Takumi Taniguchi
Kanako Yamamoto, Masayuki Takamura, Soichiro Usui, Hisayoshi Murai, Shuichi Kaneko, Department of System Biology, Kanazawa University Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa 920-8641, Japan
Takashi Yamamoto, Takumi Taniguchi, Department of Anesthesiology and Intensive Care Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-8641, Japan
Author contributions: All authors contributed to this manuscript.
Institutional review board statement: The protocol was approved by the ethical committee of Kanazawa University (AP-153421).
Institutional animal care and use committee statement: All animal protocol was performed according to the Guide for the Care and Use of Laboratory Animals in Kanazawa University, which strictly conforms to the Guide for the Care and Use of Laboratory Animals, published by the US National Institutes of Health (NIH, Bethesda, MD). The protocol was approved by the ethical committee of Kanazawa University (AP-153421).
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Data sharing statement: All data are available from the corresponding author at mtakamura@m-kanazawa.jp.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Masayuki Takamura, MD, PhD, Doctor, Senior Lecturer, Department of System Biology, Kanazawa University Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1, Takara-machi, Kanazawa 920-8641, Japan. mtakamura@m-kanazawa.jp
Telephone: +81-76-2652233 Fax: +81-76-2344250
Received: September 16, 2017
Peer-review started: September 17, 2017
First decision: November 27, 2017
Revised: December 3, 2017
Accepted: December 14, 2017
Article in press: December 14, 2017
Published online: February 4, 2018
Core Tip

Core tip: Mineralocorticoid receptor (MR) antagonists have anti-inflammatory effects in models of ischemic and reperfusion injury, suggesting potential clinical value in patients with hemorrhagic shock. However, our findings indicate that pretreatment with MR antagonists does not improve mortality rates or cytokine responses in the liver after recovery from hemorrhagic shock in rats.