Systematic Reviews
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Nov 4, 2016; 5(4): 235-250
Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.235
Plasma-Lyte 148: A clinical review
Laurence Weinberg, Neil Collins, Kiara Van Mourik, Chong Tan, Rinaldo Bellomo
Laurence Weinberg, Department of Surgery, Perioperative Pain Medicine Unit, University of Melbourne, Victoria 3084, Australia
Laurence Weinberg, Kiara Van Mourik, Chong Tan, Department of Anesthesia, Austin Hospital, Heidelberg, Melbourne, Victoria 3084, Australia
Neil Collins, Department of Anesthesia, Joondalup Health Campus, Joondalup, Perth 6027, Australia
Rinaldo Bellomo, Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, Victoria 3084, Australia
Author contributions: Weinberg L, Collins N and Van Mourik K performed the literature review and wrote the paper; Tan C and Bellomo R assisted in the writing of the manuscript.
Conflict-of-interest statement: Weinberg L is a recipient of research grants from Baxter Healthcare and is the Principle Investigator for the SPLIT-Major Surgery study. Bellomo R is a recipient of research grants from Baxter Healthcare and is a Principle Investigator for the SPLIT major surgery study. Baxter Healthcare is not involved in the design, collection of data, analyses, or interpretation of data from any Baxter sponsored fluid intervention study at the Austin Hospital. This review has been initiated and written independently of Baxter Healthcare or any other commercial institution.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Laurence Weinberg, Associate Professor, Department of Anesthesia, Austin Hospital, Studley Rd, Heidelberg, Melbourne, Victoria 3084, Australia. laurence.weinberg@austin.org.au
Telephone: +61-3-94965000 Fax: +61-3-94596421
Received: March 27, 2016
Peer-review started: March 30, 2016
First decision: May 13, 2016
Revised: September 20, 2016
Accepted: October 5, 2016
Article in press: October 9, 2016
Published online: November 4, 2016
Core Tip

Core tip: Plasma-Lyte 148 is an isotonic, buffered intravenous crystalloid solution with a physiochemical composition that closely reflects human plasma. It is physiologically different to the commonly available crystalloids solutions such as Hartmann’s solution and sodium chloride (0.9%). Before using any crystalloid solution as fluid therapy, clinicians should have a fundamental understanding of each fluids specific physiological properties.