Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Sep 9, 2025; 14(3): 101864
Published online Sep 9, 2025. doi: 10.5492/wjccm.v14.i3.101864
Correct sepsis classification–A must for antimicrobial stewardship: A longitudinal observational study
Jaideep Pilania, Prasan Kumar Panda, Udit Chauhan, Ravi Kant
Jaideep Pilania, Prasan Kumar Panda, Ravi Kant, Department of Medicine, All India Institute of Medical Sciences, Rishikesh 249203, Uttarākhand, India
Udit Chauhan, Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh 249203, Uttarākhand, India
Author contributions: Pilania J contributed to the data collection and data analysis, and was involved in manuscript writing; Panda PK provided the concept, interpreted the analysis, and critically reviewed the draft; Chauhan U and Kant R reviewed the draft. All authors have read and approved the final manuscript for publication.
Institutional review board statement: The study was reviewed and approved by Institutional Ethics Committee, AIIMS Rishikesh, ensuring patient confidentiality, data protection, and adherence to ethical standards in research involving human participants.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no conflicts of interest.
Data sharing statement: Data will be made available to others upon request to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prasan Kumar Panda, MBBS, MD, Additional Professor, Department of Medicine, All India Institute of Medical Sciences, Room No. 409 College Block, Rishikesh 249203, India. motherprasanna@rediffmail.com
Received: September 28, 2024
Revised: March 2, 2025
Accepted: March 14, 2025
Published online: September 9, 2025
Processing time: 292 Days and 20.8 Hours
Core Tip

Core Tip: Accurate sepsis classification is pivotal for clinical decision-making, optimizing antibiotic use, and combating antimicrobial resistance. The majority of the asepsis category was labelled as probable or possible sepsis and given antibiotics at initial hospitalization. The high reliance on Watch group antibiotics in empirical therapy signals a need for enhanced diagnostic strategies to refine treatment initiation, potentially reducing unnecessary antibiotic exposure.