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World J Crit Care Med. Sep 9, 2023; 12(4): 188-203
Published online Sep 9, 2023. doi: 10.5492/wjccm.v12.i4.188
Biomarkers in sepsis-looking for the Holy Grail or chasing a mirage!
Neelmani Ahuja, Anjali Mishra, Ruchi Gupta, Sumit Ray
Neelmani Ahuja, Anjali Mishra, Ruchi Gupta, Sumit Ray, Department of Critical Care Medicine, Holy Family Hospital, Delhi 110025, India
Author contributions: All the authors were equally involved in the designing, research methodology, data collection and writing of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Sumit Ray, MBBS, MD, Director, Department of Critical Care Medicine, Holy Family Hospital, Okhla Road, Delhi 110025, India.
Received: March 13, 2023
Peer-review started: March 13, 2023
First decision: April 28, 2023
Revised: May 12, 2023
Accepted: June 12, 2023
Article in press: June 12, 2023
Published online: September 9, 2023
Core Tip

Core Tip: Sepsis is defined as life threatening organ dysfunction caused by a dysregulated host response to infection. Early diagnosis of sepsis and prompt initiation of antimicrobials is essential. Biomarkers may be helpful in early diagnosis, prognostication and monitoring of response to therapy in septic patients. We review commonly used biomarkers such as procalcitonin, presepsin, soluble urokinase plasminogen activator, etc., and their utility in clinical practice.