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World J Crit Care Med. Jan 9, 2022; 11(1): 1-21
Published online Jan 9, 2022. doi: 10.5492/wjccm.v11.i1.1
Precision medicine in sepsis and septic shock: From omics to clinical tools
Juan Carlos Ruiz-Rodriguez, Erika P Plata-Menchaca, Luis Chiscano-Camón, Adolfo Ruiz-Sanmartin, Marcos Pérez-Carrasco, Clara Palmada, Vicent Ribas, Mónica Martínez-Gallo, Manuel Hernández-González, Juan J Gonzalez-Lopez, Nieves Larrosa, Ricard Ferrer
Juan Carlos Ruiz-Rodriguez, Luis Chiscano-Camón, Adolfo Ruiz-Sanmartin, Marcos Pérez-Carrasco, Clara Palmada, Ricard Ferrer, Intensive Care Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona 08035, Spain
Juan Carlos Ruiz-Rodriguez, Erika P Plata-Menchaca, Luis Chiscano-Camón, Adolfo Ruiz-Sanmartin, Marcos Pérez-Carrasco, Ricard Ferrer, Shock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, Barcelona 08035, Spain
Juan Carlos Ruiz-Rodriguez, Luis Chiscano-Camón, Adolfo Ruiz-Sanmartin, Ricard Ferrer, Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
Erika P Plata-Menchaca, Department of Intensive Care, Hospital Clínic de Barcelona, Barcelona 08036, Spain
Vicent Ribas, Data Analytics in Medicine, Digital Health Unit, Eurecat, Centre Tecnològic de Catalunya, Barcelona 08005, Spain
Mónica Martínez-Gallo, Manuel Hernández-González, Immunology Division, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona 08035, Spain
Mónica Martínez-Gallo, Manuel Hernández-González, Diagnostic Immunology Research Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, Barcelona 08035, Spain
Mónica Martínez-Gallo, Manuel Hernández-González, Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
Juan J Gonzalez-Lopez, Nieves Larrosa, Department of Clinical Microbiology, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona 08035, Spain
Juan J Gonzalez-Lopez, Nieves Larrosa, Department of Microbiology and Genetics, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
Author contributions: Ruiz-Rodríguez JC contributed to manuscript design, conception, and coordination; Plata-Menchaca EP organized the manuscript generation process and revised the style and format of the manuscript; Ruiz-Rodríguez JC, Plata-Menchaca EP, Chiscano-Camón LS, Ruiz-Sanmartin A, Pérez-Carrasco M, Palmada C, Ribas V, Gallo MM, Hernández M, González-López JJ, Larrosa MN and Ferrer R provided important intellectual contributions to each section of the manuscript, including performance of writing and revision; all authors have read and approve the final manuscript.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan Carlos Ruiz-Rodriguez, MD, PhD, Consultant Physician-Scientist, Intensive Care Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, 119, Passeig de la Vall d'Hebron, Barcelona 08035, Spain. jcruiz@vhebron.net
Received: April 26, 2021
Peer-review started: April 26, 2021
First decision: June 17, 2021
Revised: June 23, 2021
Accepted: December 22, 2021
Article in press: December 22, 2021
Published online: January 9, 2022
Core Tip

Core Tip: Sepsis is a heterogeneous disease with different clinical courses and several clinical phenotypes. Precision medicine in sepsis allows the identification of specific subgroups of patients who may benefit from a personalized approach with interventions targeted towards specific pathophysiological mechanisms.