Surgical outcomes of pulmonary resection for lung cancer after neo-adjuvant treatment

Table 6 Intraoperative/postoperative outcomes among propensity-score matched cohorts³ relative to the surgery only group (results represent odds ratios unless otherwise indicated)

Characteristic	Surgery only varied size with cohort	Chemotherapy n = 64 matched patients	Radiotherapy n = 100 matched patients	Chemo and radio n = 57 matched patients
30-d mortality (%)	1.00 (reference)	0.74 (0.16-3.43)	1.24 (0.73-2.13)	1.38 (0.79-2.43)
Overall morbidity (%)	1.00 (reference)	1.10 (0.46-2.65)	1.14 (0.80-1.62)	1.38 (1.01-1.89)1
Serious morbidity (%)	1.00 (reference)	1.25 (0.50-3.13)	1.00 (0.70-1.42)	1.00 (0.72-1.38)
Length of stay (d)2
Predicted mean difference	0.00 (reference)	-1.43 (-2.19 to -0.68)1	0.34 (0.08-0.60)1	-0.04 (-0.28-0.21)
Prolonged length of stay (%)	1.00 (reference)	0.56 (0.21-1.46)	0.95 (0.68-1.31)	0.78 (0.57-1.06)
Operative time (min)2
Predicted mean difference	0.00 (reference)	13.8 (10.7-17.0)1	19.9 (18.7-21.1)1	9.49 (8.41-10.6)1
Prolonged operative time (%)	1.00 (reference)	2.20 (1.00-4.87)1	1.56 (1.15-2.11)1	1.03 (0.79-1.34)

¹Two-sided P-values < 0.05 considered statistically significant;

²Modified Park tests corresponded to a Poisson distribution. Generalized linear models (family Poisson, link log) were used to model non-normally distributed continuous data, followed by post-estimation average marginal effects to attain predicted mean differences and 95%CI. Interpretation: Patients treated with chemotherapy had average operative times that were longer than those of surgery-only patients by 13.8 min (95%CI: 10.7-17.0); ³Separate cohorts were generated for each outcome using propensity-score-based 1:1 nearest-neighbor matching without replacement, accounting for significant baseline differences in demographic and clinical characteristics.