Published online Mar 28, 2015. doi: 10.5412/wjsp.v5.i1.75
Peer-review started: September 28, 2014
First decision: November 14, 2014
Revised: December 15, 2014
Accepted: January 9, 2015
Article in press: January 12, 2015
Published online: March 28, 2015
Core tip: Although laparoscopic surgery has been widely used for various benign colorectal diseases as well as colorectal cancer, the influence of this procedure on the tumor cell spreading is still unknown. The level of circulating tumor cells (CTCs) in patients with cancer has been reported to be significant prognostic and predictive factors. Whether laparoscopic procedure enhances tumor spreading during operation remains unknown. Significantly less CTC detected during laparoscopic surgery than open surgery for colorectal cancer has been reported. In our previous experience, we have shown that laparoscopic surgery had no significantly deleterious effect on CTCs in colorectal cancer patients.