Noncanonical intercellular communication in immune response

Table 1 Molecular content of exosomes[49,55-61,74,75]

Nucleic acids	Exosome lumen proteins	Exosome membrane proteins	Lipids
mRNA miRNA tRNA rRNA mitochondrial DNA retrotransposons	Actin Cofillin GAPDH Hsp70 Rab Tubulin	Annexins Channels EGFR FasL I-CAM1 Integrins LBPA/CD63 LAMP1/2 MHC PD-1L Tetraspanins Tsg 101	Cholesterol Diglycerides Eicosanoids fatty acids Gangliosides Lyso-phosphatidylcholine Lyso-bis phosphatidic acid Phosphatidylcholine phosp hatidylethanolamine Phosphatidylserine phosphatidylinositol Sphingomyelin

GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; I-CAM1: Intercellular adhesion molecule 1; EGFR: Epidermal growth factor receptor; LBPA: Lactoferrin-binding protein; LAMP1/2: Lysosomal-associated membrane protein 1; MHC: Major histocompatibility complex; PDL-1: Programmed death 1.