Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
Aberrant expression of CD56 by circulating Sézary syndrome malignant T lymphocytes
Nicolas Thonnart, Martine Bagot, Armand Bensussan, Anne Marie-Cardine, INSERM U976, Saint Louis Hospital, 75010 Paris, France
Nicolas Thonnart, Martine Bagot, Armand Bensussan, Anne Marie-Cardine, University Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France
Caroline Ram-Wolff, Martine Bagot, AP-HP, Department of Dermatology, Saint Louis Hospital, 75010 Paris, France
Author contributions: Marie-Cardine A designed the report and interpreted the data; Thonnart N performed the experiments; Ram-Wolff C and Bagot M were attending doctors for the patients; Ram-Wolff C, Bensussan A and Marie-Cardine A wrote the paper; Thonnart N and Ram-Wolff C equally contributed to this work.
Correspondence to: Dr. Anne Marie-Cardine, INSERM U976, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France. anne.marie-cardine@inserm.fr
Telephone: +33-1-53722050 Fax: +33-1-53722051
Received: June 27, 2013
Revised: August 28, 2013
Accepted: October 16, 2013
Published online: November 27, 2013
Revised: August 28, 2013
Accepted: October 16, 2013
Published online: November 27, 2013
Core Tip
Core tip: Sézary syndrome (SS) is an aggressive variant of cutaneous T cell lymphoma characterized by the presence of malignant CD4+ memory T cells in the skin, peripheral blood and lymph nodes. We here report a case of SS with an aberrant CD56+ immunophenotype. The aberrant expression of this natural killer cell marker by the tumoral cells raises the question of its relevance in terms of function and prognosis.