Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Urol. Mar 24, 2015; 4(1): 5-20
Published online Mar 24, 2015. doi: 10.5410/wjcu.v4.i1.5
Urological manifestations and treatment of the primary systemic vasculitides
Javeria Peracha, Matthew David Morgan
Javeria Peracha, Matthew David Morgan, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, B15 2TT Birmingham, United Kingdom
Matthew David Morgan, Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, B15 2WB Birmingham, United Kingdom
Author contributions: Peracha J and Morgan MD contributed to this paper.
Conflict-of-interest: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Matthew David Morgan, Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, B15 2WB Birmingham, United Kingdom. m.d.morgan@bham.ac.uk
Telephone: +44-121-3713223
Received: May 20, 2014
Peer-review started: May 20, 2014
First decision: June 6, 2014
Revised: November 5, 2014
Accepted: December 16, 2014
Article in press: December 17, 2014
Published online: March 24, 2015
Core Tip

Core tip: Urogenital manifestations of primary systemic vasculitides are rare. Patients will usually have other systemic signs and symptoms to suggest an underlying vasculitic process. Inflammatory markers including erythrocyte sedimentation rate and C-reactive protein are often raised and specific auto-antibody testing may be useful in identifying the underlying diagnosis. If an underlying vasculitic process is suspected, early involvement of a specialist is essential. Symptoms usually improve with immunosuppressive therapy and may avoid the need for invasive surgery. Patients who present with isolated single-organ vasculitis of the urogenital tract will need to be followed up closely in case they subsequently develop systemic disease.