Frequency of celiac disease and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with celiac disease

Table 1 The demographic and laboratory characteristics of celiac patients and their siblings

	Celiac patients, n = 57	Siblings, n = 112	P value
Age (yr)	10.30 ± 3.87	9.90 ± 6.11	0.648
Sex (female/male)	33/24	54/58	0.234
Height (cm)	132.71 ± 20.29	130.27 ± 31.37	0.594
Weight (kg)	30.44 ± 12.82	33.22 ± 19.18	0.325
Hb (g/dL)	11.65 ± 3.87	12.71 ± 1.56	< 0.001
tTG IgA (U/mL)	108.65 ± 60.61	17.24 ± 41.14	< 0.001
Total IgA (mg/dL)	155.43 ± 78.44	124.33 ± 71.47	0.014

Hb: Hemoglobin; tTG: Tissue transglutaminase antibody.

Table 2 The distribution of human leucocyte antigen genotypes of celiac patients and their siblings

HLA genotypes	Celiac patients, n = 57 (100%)	Siblings, n = 112 (100%)
HLA-DQ2	33 (57.9)	68 (60.7)
HLA-DQ2/DQ8	17 (29.8)	18 (16.1)
HLA-DQ8	6 (10.5)	15 (13.4)
Both negative	1 (1.8)	11 (9.8)

HLA: Human leucocyte antigen.

Table 3 The laboratory and clinical data of siblings of celiac patients diagnosed with celiac disease

	Patient age at diagnosis (yr)	Symptoms	Hb (g/dL)	tTG (U/mL)	IgA (mg/dL)	HLA	Pathology
1	6	Failure to thrive, anemia	10.9	140	206	DQ2	Marsh 3a
2	8.5	-	13.4	94	87	DQ8	Marsh 3a
3	18	-	13.5	105	99	DQ2	Marsh 3a
4	4.3	Failure to thrive, anemia	10.4	46	33	DQ2	Marsh 3b
5	13.5	Failure to thrive, anemia	7.7	135	254	DQ2	Marsh 3b
6	5.5	Failure to thrive, anemia	11.7	35	66	DQ2	Marsh 3b
7	16.5	Anemia	11.7	41	86	DQ2	Marsh 3b
8	16	-	13.3	187	190	DQ2	Marsh 3b
9	14.5	-	14.3	37	179	DQ2/DQ8	Marsh 2
10	12	Anemia	11.9	46	122	DQ2/DQ8	Marsh 2
11	11.5	Failure to thrive	13.1	127	148	DQ2	Marsh 3a
12	10.5	Failure to thrive, anemia	10.9	34	70	DQ2	Marsh 3b

HLA: Human leucocyte antigen; Hb: Hemoglobin; tTG: Tissue transglutaminase antibody.