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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Jul 9, 2022; 11(4): 351-359
Published online Jul 9, 2022. doi: 10.5409/wjcp.v11.i4.351
Published online Jul 9, 2022. doi: 10.5409/wjcp.v11.i4.351
Frequency of celiac disease and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with celiac disease
Yasin Sahin, Department of Pediatric Gastroenterology, Mersin Training and Research Hospital, Mersin 33240, Mersin, Turkey
Serdar Mermer, Department of Medical Genetics, Mersin Training and Research Hospital, Mersin 33240, Mersin, Turkey
Author contributions: Sahin Y designed the study, analyzed the data, interpreted the data and wrote the manuscript; Mermer S designed the study and collected and analyzed the data; All authors had read and approved the final manuscript.
Institutional review board statement: The current study was approved by the Local Ethics Committee (Toros University, Mersin, Turkey, 17.06.2020/41).
Informed consent statement: Written informed consent was not obtained as the study is retrospective. However, the Local Ethics Committee approved the current study.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yasin Sahin, MD, Associate Professor, Department of Pediatric Gastroenterology, Mersin Training and Research Hospital, Korukent Mah. 96015 Sok. Mersin Entegre Sağlık Kampüsü 33240 Toroslar/Mersin, Mersin 33240, Mersin, Turkey. ysahin977@gmail.com
Received: January 10, 2022
Peer-review started: January 10, 2022
First decision: March 8, 2022
Revised: March 18, 2022
Accepted: June 3, 2022
Article in press: June 3, 2022
Published online: July 9, 2022
Peer-review started: January 10, 2022
First decision: March 8, 2022
Revised: March 18, 2022
Accepted: June 3, 2022
Article in press: June 3, 2022
Published online: July 9, 2022
Core Tip
Core Tip: Celiac disease (CD) is a multifactorial disease, but genetic factors play a major role in its etiology. Human leucocyte antigen-DQ2/DQ8 haplotypes are one of the most important predisposing genetic factors. We detected human leucocyte antigen-DQ alleles in 98.2% of celiac patients and 100% in siblings diagnosed with CD. Also, 1 of the 2 siblings was diagnosed with CD 1 year later and the other 4 years later. Siblings of celiac patients should be followed up with clinical findings and human leucocyte antigen analysis and serological examination. We recommend that siblings should be screened for CD even if they are asymptomatic.