Copyright ©The Author(s) 2017.
World J Clin Pediatr. Aug 8, 2017; 6(3): 132-142
Published online Aug 8, 2017. doi: 10.5409/wjcp.v6.i3.132
Table 1 Potential immunological functions of vitamin D involved in the pathogenesis of lung disease
FunctionAffected immune responses
Direct down-regulation of pro-inflammatory cytokinesIL-8, IL-6, and TNF-α
Direct up-regulation of regulatory cytokinesIL-10
Up-regulation of MKP-1Inhibition of MAPKs pathways (critical for the mounting of innate immune responses)
Increase production and stabilization of IκB-αInhibition of NF-κB (regulates the expression of numerous inflammatory components)