Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Aug 8, 2017; 6(3): 132-142
Published online Aug 8, 2017. doi: 10.5409/wjcp.v6.i3.132
Role of vitamin D in cystic fibrosis and non-cystic fibrosis bronchiectasis
Maria Moustaki, Ioanna Loukou, Kostas N Priftis, Konstantinos Douros
Maria Moustaki, Ioanna Loukou, Cystic Fibrosis Unit, “Aghia Sophia” Children’s Hospital, 11527 Athens, Greece
Kostas N Priftis, Konstantinos Douros, Pediatric Allergy and Respiratory Unit, 3rd Department of Pediatrics, “Attikon” Hospital, University of Athens School of Medicine, 12462 Athens, Greece
Author contributions: Moustaki M and Loukou I wrote the first draft of the manuscript; Priftis KN and Douros K reviewed the draft, made changes, and completed the final version; all authors approved the submitted version.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Kostas N Priftis, Assistant Professor, Pediatric Allergy and Respiratory Unit, 3rd Department of Pediatrics, “Attikon” Hospital, University of Athens School of Medicine, 1 Rimini Str, 12462 Chaidari, Greece.
Telephone: +30-210-5832228 Fax: +30-210-5832229
Received: January 11, 2017
Peer-review started: January 11, 2017
First decision: February 20, 2017
Revised: May 26, 2017
Accepted: June 12, 2017
Article in press: June 13, 2017
Published online: August 8, 2017
Core Tip

Core tip: Vitamin D deficiency seems to be associated with respiratory health. Herein, we present the experimental and epidemiological data that imply a role of vitamin D deficiency in the development of cystic fibrosis (CF) and non-CF bronchiectasis. Numerous experimental data provide insight to the mechanism by which vitamin D modulates immunity, and therefore its deficiency may enhance the susceptibility to infectious diseases and affect the control of inflammation process. Epidemiological data provide evidence for the association of vitamin D deficiency and bronchiectasis, either directly or indirectly, through its relation with the risk for respiratory tract infections. This knowledge is of interest for the pediatrician as vitamin D supplementation may be a future candidate therapeutic option for bronchiectasis.