Published online Aug 8, 2017. doi: 10.5409/wjcp.v6.i3.132
Peer-review started: January 11, 2017
First decision: February 20, 2017
Revised: May 26, 2017
Accepted: June 12, 2017
Article in press: June 13, 2017
Published online: August 8, 2017
Core tip: Vitamin D deficiency seems to be associated with respiratory health. Herein, we present the experimental and epidemiological data that imply a role of vitamin D deficiency in the development of cystic fibrosis (CF) and non-CF bronchiectasis. Numerous experimental data provide insight to the mechanism by which vitamin D modulates immunity, and therefore its deficiency may enhance the susceptibility to infectious diseases and affect the control of inflammation process. Epidemiological data provide evidence for the association of vitamin D deficiency and bronchiectasis, either directly or indirectly, through its relation with the risk for respiratory tract infections. This knowledge is of interest for the pediatrician as vitamin D supplementation may be a future candidate therapeutic option for bronchiectasis.