Monogenic inflammatory bowel disease: An unfolding enigma

Figure 1 Diagnostic algorithm in a suspected case of monogenic inflammatory bowel disease. CBC: Complete blood cell count; CGD: Chronic granulomatous disease; CTLA-4: Cytotoxic T lymphocyte antigen-4; CRP: C-reactive protein; DHR: Drug hypersensitivity reactions; ESR: Erythrocyte sedimentation rate; FOXP3: Forkhead box protein 3; GOF: Gain of function; HIV: Human immunodeficiency virus; IL: Interleukin; LRBA: Lipopolysaccharide-responsive vesicle trafficking, beach-containing and anchor-containing; MCP: Monocyte chemoattractant protein; NK: Natural killer; SLCO2A1: Solute carrier organic anion transporter family member 2A1; STAT: Signal transducer and activator of transcription; TNF: Tumor necrosis factor; TTC7A: Tetratricopeptide repeat domain 7A; XIAP: X-linked inhibitors of apoptosis; UGI: Upper gastrointestinal.