Druggable monogenic immune defects hidden in diverse medical specialties: Focus on overlap syndromes

Figure 1 Symptoms and laboratory findings supportive of druggable inborn errors of immunity in various medical specialties.

Figure 2 Some druggable inborn errors of immunities in areas of intersection between more common gnoseological entities: In red druggable inborn errors of immunities and in black common gnoseological entities. JIA: Juvenile idiopathic arthritis; BD: Bowel disease; A20: A20 haploinsufficiency; HPF: hereditary periodic fever; IBD: Inflammatory bowel disease; CTLA4: Cytotoxic T-Lymphocyte antigen 4; IPEX: Immunodysregulation polyendocrinopathy enteropathy X-linked; LRBA: Lipopolysaccharide-responsive and beige-like anchor protein; STAT1: Signal transducer and activator of transcription 1; SLE: Systemic lupus erythematosus.

Figure 3 A simplified diagram for suspicion and diagnosis of druggable inborn errors of immunity in clinical practice.