Published online Apr 9, 2019. doi: 10.5409/wjcp.v8.i2.15
Peer-review started: December 5, 2018
First decision: January 21, 2019
Revised: February 3, 2019
Accepted: February 19, 2019
Article in press: February 19, 2019
Published online: April 9, 2019
Core tip: We herein present an overview of the applications of lung clearance index (LCI) in monitoring the respiratory health status of children with cystic fibrosis (CF). LCI is a more sensitive marker than spirometry and unlike spirometry it can be performed across the entire pediatric age range. At present, it is mostly used in research settings. However, as more data become available from longitudinal studies, it may be proved to be a very useful marker of respiratory status monitoring in children with CF, able to identify early those who are at risk for deterioration and allowing the early application of more aggressive interventions.