Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Apr 9, 2019; 8(2): 15-22
Published online Apr 9, 2019. doi: 10.5409/wjcp.v8.i2.15
Applications of lung clearance index in monitoring children with cystic fibrosis
Andrew Fretzayas, Konstantinos Douros, Maria Moustaki, Ioanna Loukou
Andrew Fretzayas, School of Medicine, University of Athens, Athens 11527, Greece
Andrew Fretzayas, Department of Pediatrics, Athens Medical Center, Athens University Medical School, Maroussi 15125, Greece
Konstantinos Douros, Respiratory Unit, Third Department of Pediatrics, Athens University Medical School, “Attikon” University Hospital, Haidari 12464, Greece
Maria Moustaki, Ioanna Loukou, Department of Cystic Fibrosis, “Agia Sofia”, Children’s Hospital, Athens 11527, Greece
Author contributions: Each author did equally to this work.
Conflict-of-interest statement: The authors state that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Andrew Fretzayas, MD, Doctor, Department of Pediatrics, Athens Medical Center, Athens University Medical School, 5-7 Distomou str, Maroussi 15125, Greece.
Telephone: +30-210-6157269 Fax: +30-210-6862376
Received: December 5, 2018
Peer-review started: December 5, 2018
First decision: January 21, 2019
Revised: February 3, 2019
Accepted: February 19, 2019
Article in press: February 19, 2019
Published online: April 9, 2019
Core Tip

Core tip: We herein present an overview of the applications of lung clearance index (LCI) in monitoring the respiratory health status of children with cystic fibrosis (CF). LCI is a more sensitive marker than spirometry and unlike spirometry it can be performed across the entire pediatric age range. At present, it is mostly used in research settings. However, as more data become available from longitudinal studies, it may be proved to be a very useful marker of respiratory status monitoring in children with CF, able to identify early those who are at risk for deterioration and allowing the early application of more aggressive interventions.