Published online Nov 8, 2016. doi: 10.5409/wjcp.v5.i4.383
Peer-review started: March 18, 2016
First decision: May 19, 2016
Revised: June 30, 2016
Accepted: August 15, 2016
Article in press: August 16, 2016
Published online: November 8, 2016
Core tip: Relapses in nephrotic syndrome (NS) increase morbidity and mortality. Studies have shown that zinc deficiency is common in NS. Zinc deficiency might lead to down-regulation of T-helper 1 (Th1) cytokines, a relative T-helper 2 (Th2) bias, and an increased risk of infection. The later commonly associated with relapse in NS. Zinc supplementation restores Th1-Th2 imbalance and may decrease relapse. The primary aim of this review is to evaluate the efficacy of zinc in preventing relapses in childhood NS (steroid sensitive and steroid dependent/frequent relapsing). The secondary aim is to evaluate the safety of zinc supplementation in this regard.