Published online May 8, 2016. doi: 10.5409/wjcp.v5.i2.172
Peer-review started: September 6, 2015
First decision: October 8, 2015
Revised: January 25, 2016
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: May 8, 2016
Core tip: The adverse outcomes on the offspring born from altered gestation are already known. The consequences of these perturbations have been demonstrated even after many decades from birth. In this review we summarize gestational conditions associated to fetal programming and elucidate the mechanisms involved in such kind of occurrence. We also describe to what extent oxidative stress (OS) is involved in a very wide spectrum of genetic, metabolic, and cellular responses, through the gene expression regulation, and cell growth modulation. By virtue of these properties, OS has been nominated as the lowest common denominator of adult disease programming.