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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Feb 8, 2016; 5(1): 25-34
Published online Feb 8, 2016. doi: 10.5409/wjcp.v5.i1.25
Published online Feb 8, 2016. doi: 10.5409/wjcp.v5.i1.25
Novel insights in the management of sickle cell disease in childhood
Lorenzo Iughetti, Elena Bigi, Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy
Donatella Venturelli, Transfusion Medicine Department, University Hospital of Modena, 41124 Modena, Italy
Author contributions: Iughetti L and Bigi E wrote the paper; Iughetti L and Venturelli D supervised the manuscript drafting.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lorenzo Iughetti, Associate Professor of Pediatrics, Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, via del Pozzo 71, 41124 Modena, Italy. iughetti.lorenzo@unimore.it
Telephone: +39-059-4225382
Received: July 31, 2015
Peer-review started: July 31, 2015
First decision: September 29, 2015
Revised: October 13, 2015
Accepted: December 18, 2015
Article in press: December 21, 2015
Published online: February 8, 2016
Peer-review started: July 31, 2015
First decision: September 29, 2015
Revised: October 13, 2015
Accepted: December 18, 2015
Article in press: December 21, 2015
Published online: February 8, 2016
Core Tip
Core tip: The correct management of sickle cell disease (SCD) requires a comprehensive medical care. Both a wider use of hydroxyurea and an early treatment of pain in children are needed to improve long-term outcomes. Moreover, we report in details the possibility offered by hematopoietic stem cell transplantation as a future curative option for SCD patients.