Devanarayana NM, Rajindrajith S. Gastric motility abnormalities in pediatric gastroesophageal reflux disease: A comprehensive review of mechanisms and therapeutic implications. World J Clin Pediatr 2026; 15(4): 122141 [DOI: 10.5409/wjcp.122141]
Corresponding Author of This Article
Niranga Manjuri Devanarayana, MD, PhD, Professor, Department of Physiology, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 11010, Western Province, Sri Lanka. niranga@kln.ac.lk
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
review-article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Devanarayana NM, Rajindrajith S. Gastric motility abnormalities in pediatric gastroesophageal reflux disease: A comprehensive review of mechanisms and therapeutic implications. World J Clin Pediatr 2026; 15(4): 122141 [DOI: 10.5409/wjcp.122141]
Supported by the Research Council Grant of the University of Kelaniya, Sri Lanka, No. RC/2026/PPRP 06.
Conflict-of-interest statement: Both authors report no relevant conflicts of interest for this article.
Corresponding author: Niranga Manjuri Devanarayana, MD, PhD, Professor, Department of Physiology, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 11010, Western Province, Sri Lanka. niranga@kln.ac.lk
Received: April 14, 2026 Revised: June 15, 2026 Accepted: July 13, 2026 Published online: December 9, 2026 Processing time: 158 Days and 19.9 Hours
Core Tip
Core Tip: Gastroesophageal reflux disease (GERD) is common in infants and children and significantly affects their well-being. While lower esophageal sphincter dysfunction is central to its pathophysiology, gastric dysmotility is increasingly recognized as a key contributor. This narrative review examines the relationship between gastric motor dysfunction and pediatric GERD, highlighting associated abnormalities, diagnostic challenges, and therapeutic strategies. Future research should focus on developing safe, non-invasive diagnostic tools and targeted treatments addressing gastric motility disturbances. A deeper understanding of gastric motor dysfunction will help clinicians tailor interventions, improving outcomes and quality of life of affected children.
