Liver transplantation in neurological Wilson’s disease in children: Where do we stand?

doi:10.5409/wjcp.115258

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Dec 9, 2026; 15(4): 115258
Published online Dec 9, 2026. doi: 10.5409/wjcp.115258

Liver transplantation in neurological Wilson’s disease in children: Where do we stand?

Upasana Ghosh, Nalini Kanta Ghosh

Upasana Ghosh, Department of Pediatric Gastroenterology, Post Graduate Institute of Child Health, Noida 201303, Uttar Pradesh, India

Nalini Kanta Ghosh, Department of Liver Transplantation and HPB Surgeries, Fortis Hospital, Noida 201301, Uttar Pradesh, India

Author contributions: Ghosh U wrote the initial manuscript draft; Ghosh NK designed the concept of the manuscript; Ghosh U and Ghosh NK designed the outline of the manuscript, did the literature review, and critical revision of the manuscript. All authors have read and approved the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Upasana Ghosh, Assistant Professor, Department of Pediatric Gastroenterology, Post Graduate Institute of Child Health, Sector 30, Noida 201303, Uttar Pradesh, India. ghoshupasana16@gmail.com

Received: October 15, 2025
Revised: December 17, 2025
Accepted: March 16, 2026
Published online: December 9, 2026
Processing time: 342 Days and 16.5 Hours

Core Tip

Core Tip: Liver transplantation (LT) is indicated in Wilson’s disease (WD) in acute fulminant hepatic failure or decompensated liver cirrhosis. However, LT is still debatable for neurologic WD because of advanced or irreversible brain damage. This review aims to study the current literature concerning indications, contraindications, timing and outcomes of LT among children with neurological WD.