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World J Clin Pediatr. Sep 9, 2025; 14(3): 106693
Published online Sep 9, 2025. doi: 10.5409/wjcp.v14.i3.106693
Recent advances in research on gene polymorphisms in Kawasaki disease
Zhuo-Ya Yang, Yan Pan
Zhuo-Ya Yang, Yan Pan, Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China
Author contributions: Pan Y designed the research study; Yang ZY designed the research study, performed the research, contributed new reagents and analytic tools, analyzed the data, wrote the manuscript, read and approve the final manuscript.
Conflict-of-interest statement: All the authors declare no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Pan, Researcher, Department of Pediatrics, The First Affiliated Hospital of Yangtze University, No. 55, Jianghan North Road, Jingzhou 434000, Hubei Province, China. woshipanyan@126.com
Received: March 5, 2025
Revised: March 25, 2025
Accepted: April 18, 2025
Published online: September 9, 2025
Processing time: 104 Days and 1.9 Hours
Core Tip

Core Tip: Genetic polymorphisms significantly contribute to the susceptibility, pathogenesis, and progression of Kawasaki disease (KD). These genetic variations impact immune responses, coronary artery lesions, and treatment effectiveness, offering insights into personalized diagnostic and therapeutic strategies. Advances in genomic research, particularly through genome-wide association studies and gene-environment interactions, provide a promising direction to understand the complex etiology of KD and to improve treatment outcomes.