Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Sep 9, 2023; 12(4): 237-243
Published online Sep 9, 2023. doi: 10.5409/wjcp.v12.i4.237
Transient hyperphosphatasemia in a toddler with COVID-19 infection: A case report and literature review
Pemiga Sukhupanyarak, Voraluck Phatarakijnirund
Pemiga Sukhupanyarak, Voraluck Phatarakijnirund, Division of Endocrinology, Department of Pediatrics, Phramongkutklao College of Medicine, Bangkok 10400, Thailand
Pemiga Sukhupanyarak, Division of Endocrinology, Department of Pediatrics, Buddhachinaraj Hospital, Phitsanulok 6500, Thailand
Author contributions: Sukhupanyarak P and Phatarakijnirund V contributed to manuscript writing and editing, data collection and final approval of the version of the article to be published
Informed consent statement: Subjects and legally authorized representative gave their written and verbal informed consent prior to study inclusion.
Conflict-of-interest statement: All authors state that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Voraluck Phatarakijnirund, MD, Assistant Professor, Division of Endocrinology, Department of Pediatrics, Phramongkutklao College of Medicine, No. 315 Ratchawithi Road, Phayathai, Ratchathewi, Bangkok 10400, Thailand.
Received: March 6, 2023
Peer-review started: March 6, 2023
First decision: May 9, 2023
Revised: May 25, 2023
Accepted: June 9, 2023
Article in press: June 9, 2023
Published online: September 9, 2023
Core Tip

Core Tip: Transient hyperphosphatasemia (TH) is an unrecognized condition among children under the age of 5. The only abnormality demonstrated is markedly elevated serum alkaline phosphatase (ALP) without evidence of bone or hepatic disease and spontaneous resolution occurring in several months. Numerous reports have identified various viral infections as contributing factors to the etiology of this condition. TH should be considered in coronavirus disease 2019 -infected toddlers exhibiting isolated high serum ALP. Awareness of this condition will help to avoid unnecessary investigations.