Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Jul 9, 2021; 10(4): 53-71
Published online Jul 9, 2021. doi: 10.5409/wjcp.v10.i4.53
Celiac disease in children: A review of the literature
Yasin Sahin
Yasin Sahin, Pediatric Gastroenterology-Hepatology and Nutrition, Medical Park Gaziantep Hospital, Gaziantep 27560, Turkey
Author contributions: Sahin Y wrote the paper and collected the data.
Conflict-of-interest statement: Author has nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yasin Sahin, MD, Associate Professor, Pediatric Gastroenterology-Hepatology and Nutrition, Medical Park Gaziantep Hospital, Mucahitler Mah. 52063 sok. no:2 Sehitkamil, Gaziantep 27560, Turkey.
Received: February 2, 2021
Peer-review started: February 2, 2021
First decision: March 17, 2021
Revised: March 23, 2021
Accepted: May 22, 2021
Article in press: May 22, 2021
Published online: July 9, 2021
Core Tip

Core Tip: Celiac disease is a systemic lifelong disease. The prevalence of celiac disease has increased significantly in the last three decades due to the increased awareness of physicians and widespread use of highly sensitive and specific diagnostic tests for celiac disease. Despite increased awareness and widespread use of diagnostic tests, up to 95% of celiac patients still remain undiagnosed. Early diagnosis is very important to prevent long-term complications. The only effective treatment is still a lifelong gluten-free diet. In this review, we will discuss the epidemiology, clinical findings, diagnostic tests, and treatment of celiac disease in the light of the latest literature.