Published online Jul 9, 2021. doi: 10.5409/wjcp.v10.i4.53
Peer-review started: February 2, 2021
First decision: March 17, 2021
Revised: March 23, 2021
Accepted: May 22, 2021
Article in press: May 22, 2021
Published online: July 9, 2021
Core Tip: Celiac disease is a systemic lifelong disease. The prevalence of celiac disease has increased significantly in the last three decades due to the increased awareness of physicians and widespread use of highly sensitive and specific diagnostic tests for celiac disease. Despite increased awareness and widespread use of diagnostic tests, up to 95% of celiac patients still remain undiagnosed. Early diagnosis is very important to prevent long-term complications. The only effective treatment is still a lifelong gluten-free diet. In this review, we will discuss the epidemiology, clinical findings, diagnostic tests, and treatment of celiac disease in the light of the latest literature.