Systematic Reviews
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Jan 22, 2019; 8(1): 1-14
Published online Jan 22, 2019. doi: 10.5409/wjcp.v8.i1.1
Vitamin D therapy in children with inflammatory bowel disease: A systematic review
Tarah Rigterink, Laura Appleton, Andrew S Day
Tarah Rigterink, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, the Netherlands
Tarah Rigterink, Laura Appleton, Andrew S Day, Department of Paediatrics, University of Otago Christchurch, Christchurch 8041, New Zealand
Author contributions: All authors contributed equally to the work; Day AS conceptualised and designed the review together with Rigterink T; Rigterink T and Day AS carried out the analysis; Rigterink T drafted the initial manuscript; all authors reviewed and approved the final manuscript as submitted.
Conflict-of-interest statement: All authors have no conflicts of interest to report.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Andrew S Day, MB, ChB, MD, Professor, Department of Paediatrics, University of Otago Christchurch, Riccarton Avenue, Christchurch 8041, New Zealand.
Received: October 8, 2018
Peer-review started: October 8, 2018
First decision: November 7, 2018
Revised: December 31, 2018
Accepted: January 10, 2019
Article in press: January 10, 2019
Published online: January 22, 2019
Research background

Vitamin D deficiency is commonly seen in children diagnosed with inflammatory bowel disease (IBD). While vitamin D is important for bone health, inadequate levels may also influence the course of disease.

Research motivation

To date, however, the optimal manner to correct and maintain adequate vitamin D levels in children with IBD have not been established.

Research objectives

The principal objective of this work was to systematically review the published literature focusing on vitamin D therapy in children with IBD. The further objective was to highlight opportunities for future work to augment and enhance the current understanding in this field.

Research methods

The published literature was reviewed systematically for publications that had focused on vitamin D therapy in children with IBD. The available data was then reviewed in detail.

Research conclusions

Ten published articles were identified and reviewed in detail. These reports included very different study designs with varied treatment regimens. Overall, there was no clear optimal regimen or approach that consistently corrected vitamin D deficiency and maintained levels over time.

Research perspectives

Vitamin D sufficiency is an important aspect of managing children with IBD. The available published literature does not provide a clear approach to the management of deficiency of vitamin D in this setting. Various aspects likely influence the response to vitamin D therapy: these are important factors that need to be taken into account in considering future work in this area.