Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Mar 9, 2024; 13(1): 87866
Published online Mar 9, 2024. doi: 10.5409/wjcp.v13.i1.87866
Childhood asthma biomarkers including zinc: An exploratory cross-sectional study
Hoda Atef Abdelsattar Ibrahim, Mona Mohsen, Boles Salep Aziz Hanna, Dina Mahmoud, Khaled Mohamed Abdelhamid El-Khashab
Hoda Atef Abdelsattar Ibrahim, Pediatric Clinical Nutrition Unit, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Hoda Atef Abdelsattar Ibrahim, Mona Mohsen, Boles Salep Aziz Hanna, Khaled Mohamed Abdelhamid El-Khashab, Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Dina Mahmoud, Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Author contributions: All the authors have read and approved the final manuscript. Conceptualization, material preparation, manuscript drafting/writing, editing, data interpretation and project methodology were performed by Atef Abdelsattar Ibrahim H; Resources were developed by Mohsen M, Salep Aziz Hanna B and Mahmoud D; The arrangement of diagnostic investigations and project administration were performed by Atef Abdelsattar Ibrahim H, Salep Aziz Hanna B and Mahmoud D; Supervision was performed by Atef Abdelsattar Ibrahim H, Mohsen M, Mahmoud D and Mohamed Abdelhamid El-Khashab K; Formal analysis was performed by Atef Abdelsattar Ibrahim H.
Institutional review board statement: The study was approved by the Research Ethics Committee of the Faculty of Medicine, Cairo University, No. MS-587-2021.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: The dataset of this study is available from the corresponding author upon reasonable request.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hoda Atef Abdelsattar Ibrahim, MD, Lecturer, Department of Pediatrics, Cairo University, No. 1 Gamaa Street, Giza, Cairo 12613, Egypt. hodaibrahim424@gmail.com
Received: August 30, 2023
Peer-review started: August 30, 2023
First decision: November 1, 2023
Revised: November 11, 2023
Accepted: November 29, 2023
Article in press: November 29, 2023
Published online: March 9, 2024
ARTICLE HIGHLIGHTS
Research background

Zinc levels might differ in asthmatic children.

Research motivation

The possible role of the biochemical nutritional assessment including zinc to be a biomarker for asthma severity.

Research objectives

To outline the difference in zinc levels between asthmatic and healthy children.

Research methods

A cross-sectional study was carried out investigating serum zinc levels in asthmatic and healthy children.

Research results

Zinc levels weren’t different. Ferritin levels were significantly higher in cases with bronchial asthma.

Research conclusions

Ferritin could be used as a future biomarker for asthma controller therapy.

Research perspectives

Further studies investigating the possible role of ferritin and other possible biomarkers for asthma severity should be outlined.