Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Nov 8, 2016; 5(4): 370-373
Published online Nov 8, 2016. doi: 10.5409/wjcp.v5.i4.370
Clinical profile and outcomes of pediatric endogenous endophthalmitis: A report of 11 cases from South India
Gayatri Murugan, Parag K Shah, Venkatapathy Narendran
Gayatri Murugan, Parag K Shah, Venkatapathy Narendran, Department of Pediatric Retina, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore 641014, Tamil Nadu, India
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision, editing, and final approval of the final version.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Aravind Eye Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Parag K Shah, DNB, Consultant, Department of Pediatric Retina, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Avinashi Road, Coimbatore 641014, Tamil Nadu, India.
Telephone: +91-422-4360400 Fax: +91-422-2593030
Received: June 19, 2016
Peer-review started: June 20, 2016
First decision: July 27, 2016
Revised: August 27, 2016
Accepted: October 5, 2016
Article in press: October 9, 2016
Published online: November 8, 2016

To study the clinical profile and outcomes of pediatric endogenous endophthalmitis from a tertiary eye hospital in South India.


A total of 13 eyes of 11 children presented to us with varied symptoms and presentations of endogenous endophthalmitis, over a five-year period from January 2010 to December 2015 were studied. Except for two eyes of a patient, vitreous aspirates were cultured from all 11 eyes to isolate the causative organism. These eleven eyes also received intravitreal injections. All patients were treated with systemic antibiotics.


Two cases had bilateral endophthalmitis. Ages ranged from 4 d to 11 years. Five cases were undiagnosed and treated, before being referred to our center. Ten of the 13 eyes underwent a core vitrectomy. The vitrectomy was done at an average on the second day after presenting (range 0-20 d). Five of the 11 vitreous aspirates showed isolates. The incriminating organisms were bacteria in three and fungus in two. An underlying predisposing factor was found in seven patients. At a mean follow-up 21.5 mo, outcome was good in 7 eyes of 6 cases (54%), five eyes of four cases (38%) ended up with phthisis bulbi while one child died of systemic complications.


Endogenous endophthalmitis is a challenge for ophthalmologists. Early diagnosis and intervention is the key for a better outcome.

Keywords: Pediatric, Endogenous endophthalmitis, Outcomes, South India, Fungal

Core tip: It was a retrospective study of 13 eyes of 11 children with endogenous endophthalmitis, where a detailed evaluation of the clinical profile including the presenting symptoms, signs, incriminating organisms and outcomes were studied.