Auxological and pubertal outcomes of children with Kawasaki disease: Experience from Chandigarh, India

doi:10.5409/wjcp.122376

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 4

This Article

(0)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Clinical Pediatrics

ISSN

2219-2808

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article (XML)

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Dec 9, 2026; 15(4): 122376
Published online Dec 9, 2026. doi: 10.5409/wjcp.122376

Auxological and pubertal outcomes of children with Kawasaki disease: Experience from Chandigarh, India

Sudip Thakur, Harvinder Kaur, Rakesh Kumar Pilania, Jayakanthan Kabeerdoss, Surjit Singh

Sudip Thakur, Harvinder Kaur, Child Growth and Anthropology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

Rakesh Kumar Pilania, Surjit Singh, Pediatric Allergy Immunology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

Jayakanthan Kabeerdoss, Pediatric Biochemistry Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

Co-corresponding authors: Harvinder Kaur and Rakesh Kumar Pilania.

Author contributions: Thakur S performed data collection, anthropometric assessments and drafted the manuscript; Thakur S, Kaur H, Pilania RK, Kabeerdoss J, and Singh S contributed to statistical analysis; Kaur H and Pilania RK contributed to study design; Kaur H, Pilania RK, Kabeerdoss J, and Singh S critical revision of the manuscript; Kaur H and Singh S conceptualized the study and supervised the research; Kabeerdoss J performed biochemical analyses; Kaur H and Pilania RK contributed equally to this manuscript and are co-corresponding authors. All authors approved the final version of the manuscript.

AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript, including any portions for which AI tools were used as assistive technologies. All AI-assisted outputs were carefully reviewed, validated, and approved by the authors. AI tools were not used to generate original scientific data, perform independent scientific analyses, or draw scientific conclusions.

Institutional review board statement: This study was approved by the Institutional Ethics Committee of Postgraduate Institute of Medical Education and Research (Approval No. INT/IEC/2022/SPL-1836).

Informed consent statement: Prior to participation, written informed consent from parents/guardians and patients’ assent were obtained.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.

Data sharing statement: The data is available on request to the corresponding author.

Corresponding author: Harvinder Kaur, Associate Professor, Child Growth and Anthropology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Advanced Pediatrics Centre, Sector 12, Chandigarh 160012, India. harvinderkaur315@gmail.com

Received: April 20, 2026
Revised: May 20, 2026
Accepted: June 9, 2026
Published online: December 9, 2026
Processing time: 150 Days and 23 Hours

Abstract

BACKGROUND

Kawasaki disease (KD) is an acute childhood vasculitis with potential long-term cardiovascular sequelae. However, data regarding auxological and pubertal outcomes in children with KD, particularly from developing countries, remain limited.

AIM

To study physical and pubertal growth patterns in male and female children with KD. We also aimed to examine lipid profiles and their relationship with fat distribution in KD patients at higher risk for coronary abnormalities.

METHODS

The research employed a cross-sectional approach and incorporated anthropometric evaluations, puberty assessment, and analyses of lipid profiles. 47 children with KD (32 boys and 15 girls) who were over 8 years old and had been diagnosed at least 5 years prior to the study, along with 54 healthy control participants (35 boys and 19 girls) matched for age, gender, and socioeconomic background were included in this cross-sectional study.

RESULTS

Male patients with KD demonstrated significantly higher height-for-age Z-scores, while weight-for-age Z-scores and body mass index Z-scores were numerically higher compared to controls. Female patients with KD exhibited increased height-for-age Z-scores, skinfold thickness, as well as waist and hip circumferences in comparison to the control group. KD patients demonstrated normal pubertal development, with no signs of delayed or early pubertal onset. Thirteen KD subjects (27.6%) had coronary artery abnormalities.

CONCLUSION

The study’s findings have implications for the long-term follow-up and management of KD in pediatric populations, suggesting that children with KD generally demonstrate normal growth and pubertal development comparable to healthy controls.

Keywords: Auxology; Height-for-Age; Weight-for-Age; Normal growth; Kawasaki disease; Puberty; Sexual maturity rating

Core Tip: Kawasaki disease (KD) is an acute childhood vasculitis with potential long-term cardiovascular sequelae; however, data regarding growth and pubertal outcomes remain limited. In this cross-sectional study, children with KD demonstrated auxological and pubertal parameters broadly comparable to healthy controls. Coronary artery abnormalities were not associated with major differences in anthropometric measures. These findings contribute to the limited literature on long-term developmental outcomes in KD, particularly from Indian populations, and highlight the need for larger longitudinal studies.