Molecular biomarkers of cell proliferation in ameloblastomas

Table 1 Cell proliferative activity measured using Ki-67 and/or proliferating cell nuclear antigen antibodies in ameloblastomas

Ref.	n	Type (n)	Ki-67	PCNA
Kim et al[40]	38	Unicystic (13)		+
		Solid/Multicystic (25)
		Follicular		+
		Plexiform
		Acanthomatous
		Granular
		Basal Cell
		Ameloblastic Carcinoma		+
Fonaoka et al[41]	23	Plexiform (15)		++
		Follicular (5)		+++
		Unicystic (3)		+
Ong’uti et al[18]	54	Plexiform (30)	+
		Follicular (24)	++
Piatelli et al[42]	22	Unicystic (5)		+
		Solid/Multicystic (13)
		Plexiform (5)		++++
		Follicular (4)		++
		Acanthomatous (4)		+++
Nagao et al[43]	30	Plexiform (15)	++
		Follicular (15)	+
Sandra et al[12]	32	Plexiform (9)	++++	++++
		Follicular (9)	+++++	+++++
		Acanthomatous (3)	+++	+++
		Basal Cell (3)	++++++	++++++
		Desmoplastic (3)	+	++
		Unicystic (5)	++	+
Han et al[19]	70	Follicular (ND)	+++
		Plexiform (ND)	++
		Unicystic (ND)	+
Meer et al[15]	20	Solid/Multicystic (10)	+	+
		Unicystic (10)	++	++
Galvão et al[44]	16	Follicular (7)		++++
		Plexiform (4)		++
		Acanthomatous (3)		+++
		Basal Cell (2)		+
Bologna-Molina et al[3,13,45]	120	Solid/Multicystic (66)	+++	+++
	10	Unicystic (87)	++++	++++
	161	Peripheral (3)	++	++
		Desmoplastic (5)	+	+
		Ameloblastic Carcinoma (4)	+++++	+++++
Rizzardi et al[14]	15	Peripheral (2)	+++
		Unicystic (2)	++
		Solid/Multicystic (11)	+
Salehinejad[46]	30	Plexiform (15)		+
		Follicular (12)		+
		Acanthomatous (3)		++
Yoon et al[47]	17	Ameloblastomas (10)	+
		Ameloblastic Carcinoma (7)	++
Maya et al[21]	15	Plexiform		+++
		Follicular		++
		Unicystic		+

The table describes the immunohistochemical studies performed with markers proliferating cell nuclear antigen and Ki-67 from the year 1994 to date. PCNA: Proliferating cell nuclear antigen.