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World J Stomatol. Nov 20, 2013; 2(4): 79-85
Published online Nov 20, 2013. doi: 10.5321/wjs.v2.i4.79
Molecular biomarkers of cell proliferation in ameloblastomas
Ronell Bologna-Molina, Ana Maria Bedoya-Borella, Liliana Soria-Moreira, Sandra Soría-Suárez
Ronell Bologna-Molina, Molecular Pathology, School of Dentistry, Universidad de la República (UDELAR), Montevideo 11600, Uruguay
Ana Maria Bedoya-Borella, Biology Department, CBC, Universidad de Buenos Aires (UBA), Buenos Aires C1122AAH, Argentina
Liliana Soria-Moreira, Anatomy Pathology, School of Dentistry, Universidad de la República (UDELAR), Montevideo 11600, Uruguay
Sandra Soría-Suárez, Biotechnology Laboratory Solutions (LASOBIOTC), Montevideo 11600, Uruguay
Author contributions: Bologna-Molina R wrote, revised the manuscript and designed the figures; Bedoya-Borella AM, Soria-Moreira L and Soría-Suárez S contributed equally to the writing of the manuscript.
Correspondence to: Ronell Bologna-Molina, DDS, PhD, Molecular Pathology, School of Dentistry, Universidad de la República (UDELAR), Las Heras 1925, Montevideo 11600, Uruguay. ronellbologna@hotmail.com
Telephone: +598-2-4873048 Fax: +598-2-4008640
Received: June 29, 2013
Revised: August 12, 2013
Accepted: August 20, 2013
Published online: November 20, 2013
Core Tip

Core tip: Specific molecular markers are characteristic of particular cellular events such as proliferation, and in this context, “proliferation markers” refer to specific proteins or other factors in actively growing and dividing cells, whose presence serves as an indicator for such cells. In this mini-review, we aim to provide an overview of the methods currently available for the assessment of proliferation, and we review the different cell proliferation markers used to assess the biological behavior of ameloblastomas. In addition, we propose a new maker.