Dental pulp stem cells: Novel cell-based and cell-free therapy for peripheral nerve repair

Table 3 Studies retrieved from PubMed database evaluating the effect of DPSCs on nerve repair or regeneration in-vitro

Author	Publication year	Source of stem cells	Target tissues	Objective	Outcome
Geng et al[84], 2017	2017	Human DPSCs	Differentiation of hDPSCs.	To demonstrate the differentiating ability of resveratrol on DPSCs.	Resveratrol induced DPSCs differentiation into neuroprogenitor cells. DPSCs might be an important cell population for neurological disease treatment.
Hafner et al[85], 2017	2017	Human DPSCs	Spider dragline silk fibers	To evaluating adhesion and alignment of dental pulp stem cells to a spider silk substrate for tissue engineering applications.	Natural drawn spider silk acted as an effective substrate for cellular adhesion and alignment of DPSCs and could be used in neural differentiation applications.
Chang et al[86], 2014	2014	Human DPSCs	Medium preparation for the induction of spinal motor neuronal differentiation; Medium preparation for the induction of dopaminergic neuronal differentiation	To evaluate the efficacy of dopaminergic and motor neuronal inductive media on transdifferentiation of human DPSCs (hDPSCs) into neuron-like cells.	Human DPSCs-derived dopaminergic and spinal motor neuron cells after induction expressed a higher density of neuron cell markers than those before induction.
Mead et al[60], 2014	2014	Human DPSC, human BMSCs human AMSCs	Axotomised adult rat retinal ganglion cells	To evaluate the therapeutic potential for neurodegenerative conditions of retinal ganglion cells.	Human DPSCs promoted significant multi-factorial paracrine-mediated retinal ganglion cell survival and neurite outgrowth compared with Human BMSCs/Human AMSCs.
Martens et al[23], 2014	2014	Human DPSCs	Dorsal root ganglia	Evaluated the differentiation potential of human DPSCs toward SCs, together with their functional capacity with regard to myelination and support of neurite outgrowth.	Human DPSCs are able to undergo SCs differentiation and support neural outgrowth.

DPSCs: Dental pulp stem cells; BMSCs: Bone marrow stem cells; AMSCs: Adipose mesenchymal stem cells.