Published online Jan 15, 2019. doi: 10.5321/wjs.v7.i1.1
Peer-review started: August 22, 2018
First decision: October 14, 2018
Revised: November 15, 2018
Accepted: January 8, 2019
Article in press: January 8, 2019
Published online: January 15, 2019
Core tip: The distinct developmental pathway of dental pulp stem cells (DPSCs) from neural crest cells results in a cell type that can be participate in neural tissue regeneration. The efficacy of using DPSCs for peripheral nerve repair (PNR) is strongly influenced by boosting trophic factors that promote axonal growth and regeneration and provide direct and indirect protection against cell death. Recently, encouraging results from different studies indicate that DPSC secretomes have reparative and protective properties comparable with their cellular counterparts in PNR. The use of DPSC secretomes as a safe and possibly more valuable substitute for cell-based therapy approaches is a novel therapeutic perspective.