Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stomatol. Jan 15, 2019; 7(1): 1-19
Published online Jan 15, 2019. doi: 10.5321/wjs.v7.i1.1
Dental pulp stem cells: Novel cell-based and cell-free therapy for peripheral nerve repair
Nessma Sultan, Laila E Amin, Ahmed R Zaher, Ben A Scheven, Mohammed E Grawish
Nessma Sultan, Laila E Amin, Ahmed R Zaher, Mohammed E Grawish, Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt
Ben A Scheven, School of Dentistry, Oral Biology, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, United Kingdom
Author contributions: Sultan N generated the figure, table and wrote the manuscript; Grawish ME, Amin LE, Zaher AR and Scheven BA contributed to writing of the manuscript, provided intellectual contribution to the content, and made critical revisions; all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mohammed E Grawish, PhD, Professor, Department of Oral Biology, Faculty of Dentistry, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt.
Telephone: +20-50-2200706
Received: August 21, 2018
Peer-review started: August 22, 2018
First decision: October 14, 2018
Revised: November 15, 2018
Accepted: January 8, 2019
Article in press: January 8, 2019
Published online: January 15, 2019
Core Tip

Core tip: The distinct developmental pathway of dental pulp stem cells (DPSCs) from neural crest cells results in a cell type that can be participate in neural tissue regeneration. The efficacy of using DPSCs for peripheral nerve repair (PNR) is strongly influenced by boosting trophic factors that promote axonal growth and regeneration and provide direct and indirect protection against cell death. Recently, encouraging results from different studies indicate that DPSC secretomes have reparative and protective properties comparable with their cellular counterparts in PNR. The use of DPSC secretomes as a safe and possibly more valuable substitute for cell-based therapy approaches is a novel therapeutic perspective.