Published online Nov 26, 2018. doi: 10.5321/wjs.v6.i2.6
Peer-review started: July 23, 2018
First decision: August 20, 2018
Revised: August 31, 2018
Accepted: November 13, 2018
Article in press: November 14, 2018
Published online: November 26, 2018
Core tip: Advancements in molecular biology has progressed exponentially in the past decade enabling the diagnosis and treatment of various oral and maxillofacial diseases including cancer. Next generation sequencing is one such tool which is used to determine the genetic make up of an individual as well as in identification of various genetic imbalances that occur in human diseases. Knowledge of the various sequencing methods and the genetic abnormalities may aid in its clinical application for overall improvement in disease diagnosis and prognosis.