Published online Aug 20, 2015. doi: 10.5321/wjs.v4.i3.115
Peer-review started: January 27, 2015
First decision: April 10, 2015
Revised: May 10, 2015
Accepted: August 16, 2015
Article in press: August 17, 2015
Published online: August 20, 2015
Core tip: The overall 5-year survival rates for oral cancer have remained low (50%) for the past decades and are considered among the worst of all cancer death rates. Despite the obvious advantage of earlier diagnosis of oral cancer, no approach has yet proven to be a reliably successful in diagnosis of oral cancer at an early stage. Currently, the primary line of screening of oral cancer is performed by subjective visual inspection. Recent advancements in oral cancer research have led to the development of potentially useful diagnostic tools at the clinical and molecular level for early detection of oral cancer.