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World J Stomatol. Nov 20, 2013; 2(4): 86-90
Published online Nov 20, 2013. doi: 10.5321/wjs.v2.i4.86
Published online Nov 20, 2013. doi: 10.5321/wjs.v2.i4.86
Cytotoxicity of a silorane-based dental composite on human gingival fibroblasts
Giovanna Orsini, Alberto Catellani, Angelo Putignano, Department of Clinical Sciences and Stomatology, Polytechnic University of Marche, 66020 Ancona, Italy
Concetta Ferretti, Monica Mattioli-Belmonte, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 66020 Ancona, Italy
Marco Gesi, Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy
Author contributions: Orsini G and Catellani A wrote the paper; Ferretti C performed cell cultures and Mattioli-Belmonte M performed the scanning electron microscope and the statistical analyses; Orsini G and Putignano A designed the research; Gesi M helped for revision and editing of the final paper.
Correspondence to: Giovanna Orsini, DDS, PhD, Associate Professor, Department of Clinical Sciences and Stomatology, Polytechnic University of Marche, Via Tronto 10, 66020 Ancona, Italy. giovorsini@yahoo.com
Telephone: +39-71-2206224 Fax: +39-71-2202324
Received: June 13, 2013
Revised: August 5, 2013
Accepted: August 20, 2013
Published online: November 20, 2013
Revised: August 5, 2013
Accepted: August 20, 2013
Published online: November 20, 2013
Core Tip
Core tip: The behaviour of silorane-based materials seems to be comparable to the one observed for conventional composite material, thus decreasing the cytotoxicity after long time exposure. Further studies are still needed to characterize the biological response of these methacrylate-free composite formulations, in order to definitely demonstrate their safe use in restorative dentistry.