Published online Nov 5, 2020. doi: 10.5320/wjr.v10.i2.11
Peer-review started: April 30, 2020
First decision: July 4, 2020
Revised: August 22, 2020
Accepted: September 8, 2020
Article in press: September 8, 2020
Published online: November 5, 2020
Core Tip: Chronic obstructive pulmonary disease (COPD) patients and the exacerbations they suffer are complex and heterogenous in nature. They should all be treated on an individual basis with detailed clinical history and initial work up to better understand the impact it is having on their life. Careful consideration of the benefits of treatment should be weighed up against the risks of their side effects to ensure the maximum benefit of treatment. Precision medicine is starting to appear in management of COPD, both for acute exacerbations and their prevention.