Published online Jul 28, 2017. doi: 10.5320/wjr.v7.i2.39
Peer-review started: November 3, 2016
First decision: February 16, 2017
Revised: March 15, 2017
Accepted: April 16, 2017
Article in press: April 17, 2017
Published online: July 28, 2017
The data on quantitative and qualitative microbial composition of the respiratory tract of healthy individuals revealed significant differences when compared with the microbiota of patients suffering from respiratory diseases. Possible etiological role of microbiota in pulmonary diseases as well as drug resistance development is of profound interest nowadays. Numerous studies have provided evidence confirming the relationship between gut microbiome and those of lungs. This relationship could explain how changes in the microbial communities in one organ may lead to pathological changes in the other. Till date, some progress has been made in the study of the biological properties of probiotic bacteria, considering their modulating effect on inflammatory immune response. The use of probiotics which exhibits an immunomodulatory potential looks promising.
Core tip: The role of the respiratory tract microbiota in a healthy state and in respiratory diseases is broadly discussed nowadays. There is also a big amount of data regarding contribution of gastrointestinal microbiota changes in respiratory diseases development. A gut-lung axis conception is of great interest. Perspective of prebiotics and probiotics application in lung diseases treatment looks very promising. Huge number of researches has been done on topics mentioned above. Our objective is to consolidate the current literature to summarize the most recent and most important data concerning this subject.