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Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Respirol. Mar 28, 2015; 5(1): 4-16
Published online Mar 28, 2015. doi: 10.5320/wjr.v5.i1.4
Historical transition of management of sarcoidosis
Minoru Inomata, Satoshi Konno, Arata Azuma
Minoru Inomata, Arata Azuma, Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan
Satoshi Konno, First Department of Medicine, Hokkaido University School of Medicine, Kita-ku, Sapporo 060-8638, Japan
Author contributions: Inomata M and Konno S equally contributed to this paper; Azuma A revised the manuscript critically for important intellectual content.
Supported by Arata Azuma has received grants from Ministry of Health, Welfare and Labor of Japan.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Arata Azuma, MD, PhD, Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. a-azuma@nms.ac.jp
Telephone: +81-3-38222131 Fax: +81-3-56853075
Received: October 23, 2014
Peer-review started: October 24, 2014
First decision: January 8, 2015
Revised: January 24, 2015
Accepted: February 9, 2015
Article in press: February 10, 2015
Published online: March 28, 2015
Processing time: 175 Days and 16.1 Hours
Abstract

Sarcoidosis is a systemic granulomatous disease of undetermined etiology, and it primarily affects the lungs and lymphatic system but may involve other organs. Recently, there have been several new insights in Japanese patients. The frequency of cardiac, ocular, and cutaneous sarcoidosis has increased in Japan, whereas, the proportion of patients with bilateral hilar lymphadenopathy decreased from 1960 to 2004. Propionibacterium acnes (P. acnes) has been studied extensively as one of the causative microorganism for granuloma formation, particularly in Japan. P. acnes-specific monoclonal antibodies are useful for diagnosing sarcoidosis. The potential association between smoking and sarcoidosis has been evaluated in a Japanese study, which found a higher prevalence of sarcoidosis among young smokers than that in previous reports. Recently, 18F-fluorodeoxyglucose positron-emission tomography, which permits visualization of activated inflammation, and endobronchial ultrasonography-guided transbronchial needle aspiration have been increasingly used to diagnose sarcoidosis. Cardiac sarcoidosis is found to be the main cause of death in Japan. The 2006 revised Japanese guidelines for diagnosing cardiac sarcoidosis are useful, particularly for subclinical cardiac sarcoidosis patients. Further studies and international communication and evaluation are needed to determine the causes of sarcoidosis, identify the risk factors for progressive disease, and develop new and effective treatments.

Keywords: Japan; Propionibacterium acnes; Smoking; Cardiac sarcoidosis; Positron-emission tomography; Endobronchial ultrasonography-guided transbronchial needle aspiration

Core tip: Sarcoidosis, a systemic granulomatous disease of undetermined etiology, is characterized by a variable clinical presentation and course. Propionibacterium acnes (P. acnes)-specific monoclonal antibodies can detect P. acnes, a causative microorganism, and are useful for diagnosing sarcoidosis. The importance of 18F-fluorodeoxyglucose positron-emission tomography and endobronchial ultrasonography-guided transbronchial needle aspiration to diagnose sarcoidosis is progressively increasing. Cardiac sarcoidosis is the main cause of death in Japan. The 2006 Japanese guidelines for diagnosing cardiac sarcoidosis are useful, particularly for subclinical cardiac sarcoidosis patients. Further studies and international communication and evaluation are needed to improve our management of sarcoidosis.