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Watanabe T, Kaira K, Mizuide M, Sunaga N, Shibusawa N, Hisada T, Satoh T, Mori M, Yamada M. Solitary pituitary metastasis resulting from pulmonary large cell neuroendocrine carcinoma. World J Respirol 2014; 4(1): 8-10 [DOI: 10.5320/wjr.v4.i1.8]
Takuya Watanabe, Kyoichi Kaira, Masafumi Mizuide, Noriaki Sunaga, Nobuyuki Shibusawa, Takeshi Hisada, Tetsurou Satoh, Masatomo Mori, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan
Author contributions: Watanabe T and Kaira K designed the research, acquired the patient data and drafted the paper; Mizuide M and Shibusawa N collected and reviewed the patient’s information; Sunaga N, Hisada T and Satoh T advised on the management of the patient; Mori M and Yamada M made critical revisions to the manuscript. All authors read and approved the final manuscript.
Correspondence to: Kyoichi Kaira, MD, PhD, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511, Japan. kkaira1970@yahoo.co.jp
Telephone: +81-27-2208136 Fax: +81-27-2208136
Received: July 12, 2013 Revised: October 16, 2013 Accepted: March 3, 2014 Published online: March 28, 2014 Processing time: 258 Days and 0.9 Hours
Abstract
Solitary pituitary metastasis is a rare phenomenon in human neoplasms. We report a case of lung cancer with the initial manifestation of endocrinopathy resulting from pituitary metastasis. The patient’s initial diagnosis was a poorly differentiated carcinoma, however, morbid anatomy revealed a definite diagnosis of large cell neuroendocrine carcinoma (LCNEC). Clinical physicians should be aware of potential initial manifestations such as endocrine abnormalities including panhypopituitarism and diabetes insipidus due to solitary pituitary metastasis. This case demonstrates that an endocrine abnormality such as panhypopituitarism could be an initial manifestation of LCNEC.
Core tip: Solitary pituitary metastasis is a rare phenomenon in human neoplasms. An endocrine abnormality such as panhypopituitarism could be an initial manifestation of large cell neuroendocrine carcinoma.
