Published online Nov 12, 2015. doi: 10.5318/wjo.v5.i4.142
Peer-review started: February 22, 2015
First decision: June 3, 2015
Revised: June 23, 2015
Accepted: August 13, 2015
Article in press: August 14, 2015
Published online: November 12, 2015
Core tip: Drugs that prevent the binding of vascular endothelial growth factor (VEGF) produce greater gains in best corrected visual than can be achieved with laser photocoagulation. The recently completed pivotal phase III trials showed that regular injections of ranibizumab and aflibercept over 2 years also improved the severity of diabetic retinopathy (DR). Both drugs have now been approved for the treatment of DR in patients with diabetic macular edema (DME) thereby allowing physicians to consider VEGF inhibition to improve DR in patients with vision threatening DME.