Published online Aug 12, 2015. doi: 10.5318/wjo.v5.i3.133
Peer-review started: December 2, 2014
First decision: February 7, 2015
Revised: May 24, 2015
Accepted: May 27, 2015
Article in press: May 28, 2015
Published online: August 12, 2015
Core tip: Diabetic retinopathy is one of the prominent reasons of vision loss in the industrial countries. Among these patients, diabetic macular edema (DME) is the main reason of vision impairment. Previous studies have shown that vascular endothelial growth factor (VEGF) has a major role in the pathogenesis of diabetic retinopathy and DME, as well as demonstrated favorable results for DME treatment. This review summarizes the outcomes of clinical trials that evaluated anti-VEGF agents including pegaptanib, ranibizumab, bevacizumab, and aflibercept in DME treatment.