Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Ophthalmol. Feb 12, 2015; 5(1): 23-30
Published online Feb 12, 2015. doi: 10.5318/wjo.v5.i1.23
Cerium oxide nanoparticles as promising ophthalmic therapeutics for the treatment of retinal diseases
Svetlana V Kyosseva, James F McGinnis
Svetlana V Kyosseva, Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
James F McGinnis, Department of Ophthalmology/Dean McGee Eye Institute and Department of Cell Biology, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
Author contributions: Kyosseva SV and McGinnis JF contributed equally to this work.
Supported by NIH NEI, No. R21EY018306, R01EY18724, R01EY022111; National Science Foundation, No. CBET-0708172.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Svetlana V Kyosseva, PhD, Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, United States.
Telephone: +1-501-5264201 Fax: +1-501-6031146
Received: May 29, 2014
Peer-review started: May 29, 2014
First decision: June 18, 2014
Revised: November 3, 2014
Accepted: November 17, 2014
Article in press: November 19, 2014
Published online: February 12, 2015
Core Tip

Core tip: This review outlines the recent findings that cerium oxide nanoparticles (nanoceria) may represent novel and broad spectrum therapeutic agents to treat retinal diseases including age-related macular degeneration, retinal angiomatous, inherited retinal degeneration, and fight inflammation and pathologies associated with oxidative stress.