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World J Ophthalmol. Aug 12, 2014; 4(3): 29-34
Published online Aug 12, 2014. doi: 10.5318/wjo.v4.i3.29
Blue light induced retinal oxidative stress: Implications for macular degeneration
Richard HW Funk, Ulrike Schumann, Katrin Engelmann, Klio A Becker, Cora Roehlecke
Richard HW Funk, Ulrike Schumann, Katrin Engelmann, Cora Roehlecke, Institut für Anatomie, Medizinische Fakultät der TU Dresden, 01307 Dresden, Germany
Richard HW Funk, Katrin Engelmann, CRTD/Center for Regenerative Therapies Dresden/DFG-Research Center and Cluster of Excellence, TU Dresden, 01307 Dresden, Germany
Katrin Engelmann, Klio A Becker, Augenklinik, Klinikum Chemnitz gGmbH, 09116 Chemnitz, Germany
Author contributions: Funk RHW contributed to drafting the article and final approval of the version to be published; Schumann U contributed to substantial contributions to acquisition of data, analysis and interpretation of data; Engelmann K contributed to substantial contributions to acquisition of data, analysis and interpretation of data; Becker KA contributed to substantial contributions to acquisition of data, analysis and interpretation of data; Roehlecke C contributed to substantial contributions to acquisition of data, analysis and interpretation of data.
Correspondence to: Dr. Richard HW Funk, Professor, Institut für Anatomie, Medizinische Fakultät der TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany. richard.funk@tu-dresden.de
Telephone: +49-351-4586110 Fax: +49-351-4586303
Received: February 13, 2014
Revised: May 23, 2014
Accepted: June 10, 2014
Published online: August 12, 2014
Core Tip

Core tip: The role of blue light and oxidative stress in the pathogenesis of retinal degenerative diseases like age related macular degeneration is still under debate. Recent studies including ours have demonstrated that all molecules of the respiratory chain are present in the outer segment of the photoreceptors-also being the source of reactive oxygen species-even more than the reactive oxygen species production in inner segment mitochondria. These two new findings have also important implications for many degenerative diseases of the retina. In this respect we revisited the literature regarding the photoreceptor reactions after blue light and radical stress.